Combination antiretroviral therapy has had a dramatic effect in reducing morbidity and mortality associated with human immunodeficiency virus type 1 (HIV-1) infection. 1 2 3 4 However, concern has been raised regarding the effect of such therapy on the risk of coronary heart disease. Previous…

Several epidemiologic studies 1 2 3 4 5 6 7 have demonstrated that systolic and diastolic blood pressures have a “strong, continuous, graded and etiologically significant” positive association with cardiovascular-disease outcomes. 1 These relations are consistent in both men and women, in young,…